| Autor: |
Risinger FO; Department of Medical Psychology, Oregon Health Sciences University, Portland 97201-3098., Dickinson SD, Cunningham CL |
| Jazyk: |
angličtina |
| Zdroj: |
Psychopharmacology [Psychopharmacology (Berl)] 1992; Vol. 107 (2-3), pp. 453-6. |
| DOI: |
10.1007/BF02245175 |
| Abstrakt: |
This experiment examined the impact of a dopamine receptor blocker on ethanol's rewarding effect in a place conditioning paradigm. DBA/2J mice received four pairings of a tactile stimulus with ethanol (2 g/kg, IP), haloperidol (0.1 mg/kg, IP)+ethanol, or haloperidol alone. A different stimulus was paired with saline. Ethanol produced increases in locomotor activity that were reduced by haloperidol. However, conditioned preference for the ethanol-paired stimulus was not affected by haloperidol. Haloperidol alone decreased locomotor activity during conditioning and produced a place aversion. These results indicate a dissociation of ethanol's activating and rewarding effects. Moreover, they suggest that ethanol's ability to induce conditioned place preference is mediated by nondopaminergic mechanisms. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full text from SpringerLink