Serum total cholesterol, triglycerides and high density lipoproteins (HDL) levels in rabbit during the course of experimental diabetes.

Autor: Wójtowicz Z; Department of Human Anatomy, Skubiszewski Medical University of Lublin., Wrona W, Kiś G, Błaszczak M, Solecka A
Jazyk: angličtina
Zdroj: Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina [Ann Univ Mariae Curie Sklodowska Med] 2004; Vol. 59 (2), pp. 258-60.
Abstrakt: The study was conducted on 56 rabbits, of White New Zealand breed, male gender. The average weight of the rabbits was 3 kg. The diabetes was evoked by intravenous injection of 10% alloxan, using the single dose of 100 mg/kg. On the 7th day after administration of alloxan, serum glucose levels were determined. The serum glucose level higher than 11.1 mmol/l was considered an indicator of the presence of diabetes. All the animals included in the study were divided into five groups: the control, 21-day diabetes, 42-day diabetes, 90-day diabetes and 180-day diabetes. Serum total cholesterol, triglycerides and high density lipoproteins levels were determined with enzymatic methods. Our studies revealed a significant increase in cholesterol and triglycerides levels. That mechanism might be responsible for faster development of atheromatosis during the course of diabetes mellitus.
Databáze: MEDLINE