| Autor: |
Zhou B; Immunology Program, Benaroya Research Institute, Seattle, Washington 98101, USA., Comeau MR, De Smedt T, Liggitt HD, Dahl ME, Lewis DB, Gyarmati D, Aye T, Campbell DJ, Ziegler SF |
| Jazyk: |
angličtina |
| Zdroj: |
Nature immunology [Nat Immunol] 2005 Oct; Vol. 6 (10), pp. 1047-53. Date of Electronic Publication: 2005 Sep 04. |
| DOI: |
10.1038/ni1247 |
| Abstrakt: |
The cytokine thymic stromal lymphopoietin (TSLP) has been linked to human allergic inflammatory diseases. We show here that TSLP expression was increased in the lungs of mice with antigen-induced asthma, whereas TSLP receptor-deficient mice had considerably attenuated disease. Lung-specific expression of a Tslp transgene induced airway inflammation and hyperreactivity characterized by T helper type 2 cytokines and increased immunoglobulin E. The lungs of Tslp-transgenic mice showed massive infiltration of leukocytes, goblet cell hyperplasia and subepithelial fibrosis. TSLP was capable of activating bone marrow-derived dendritic cells to upregulate costimulatory molecules and produce the T helper type 2 cell-attracting chemokine CCL17. These findings suggest that TSLP is an important factor necessary and sufficient for the initiation of allergic airway inflammation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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