| Autor: |
Poehlmann TG; Department of Obstetrics, Friedrich Schiller University, Jena, Germany., Busch S, Mussil B, Winzer H, Weinert J, Mebes I, Schaumann A, Fitzgerald JS, Markert UR |
| Jazyk: |
angličtina |
| Zdroj: |
Chemical immunology and allergy [Chem Immunol Allergy] 2005; Vol. 89, pp. 26-35. |
| DOI: |
10.1159/000087907 |
| Abstrakt: |
Pregnancy is accompanied by a Th2-prone immune modulation, which is a major puzzle piece among maternofetal tolerance-promoting factors. A large number of cytokines is physiologically or pathologically present in the decidua and is potentially able to act on lymphocytes and NK cells, which express a variety of respective receptors. Intracellular signals from these receptors are to a major part transduced via the Janus kinases (JAK) and signal transducers and activators of a transcription (STAT) system, which consists of at least 4 different kinases and 7 STATs plus several subtypes and splicing variants. A network of suppressors of cytokine signaling (SOCS) controls their balance. The interactions of all these intracellular factors and cross-linking with further signaling systems seem to be crucial for the maintenance of a maternal cytokine profile which promotes the tolerance of the fetus. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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