| Autor: |
Swiader MJ; Department of Pharmacology and Toxicology, Medical University of Lublin, Lublin, Poland., Luszczki JJ, Pilip S, Kozicka M, Parada-Turska J, Czuczwar SJ |
| Jazyk: |
angličtina |
| Zdroj: |
Pharmacological reports : PR [Pharmacol Rep] 2005 Jul-Aug; Vol. 57 (4), pp. 536-9. |
| Abstrakt: |
Omeprazole is a commonly prescribed drug for patients with peptic ulcerations. Its main mechanism of action is related to inhibition of H(+)-K(+)-ATP-ase, albeit it may also block carbonic anhydrase. This study evaluates the effects of acute and prolonged (3- or 7-day) intragastrical administration of omeprazole on the anticonvulsant activity of carbamazepine or diphenylhydantoin against maximal electroshock-induced seizures in mice. Omeprazole administered acutely, for 3 days or 7 days did not alter the electroconvulsive threshold in mice. Moreover, the drug did not affect the anticonvulsant activity of the tested antiepileptic drugs. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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