Synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-one/thione-5-one derivatives and evaluation as antibacterials.
| Autor: | Kidwai M; Department of Chemistry, University of Delhi, Delhi 110007, India. kidwai_chemistry@yahoo.co.uk, Saxena S, Khan MK, Thukral SS |
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| Jazyk: | angličtina |
| Zdroj: | European journal of medicinal chemistry [Eur J Med Chem] 2005 Aug; Vol. 40 (8), pp. 816-9. Date of Electronic Publication: 2005 Apr 01. |
| DOI: | 10.1016/j.ejmech.2005.02.009 |
| Abstrakt: | A novel, ecofriendly, one pot solvent free method for the synthesis of 4-aryl-7,7-dimethyl-1,2,3,4,5,6,7,8-octahydroquinazoline-2-one/thione-5-one derivatives is described which devoids the use of any organic solvents and auxiliaries. All the synthesized compounds were screened for their in vitro antibacterial activity against standard strains of Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. |
| Databáze: | MEDLINE |
| Externí odkaz: |
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