Antibody-based approaches to diagnosis and characterization of oxidative phosphorylation diseases.

Autor: Hanson BJ; Institute of Molecular Biology, University of Oregon, Eugene, OR 97403 1229, USA., Marusich MF, Capaldi RA
Jazyk: angličtina
Zdroj: Mitochondrion [Mitochondrion] 2001 Oct; Vol. 1 (3), pp. 237-48.
DOI: 10.1016/s1567-7249(01)00026-5
Abstrakt: Mitochondrial disorders caused by defects in oxidative phosphorylation function are difficult to diagnose. Here we review the emerging use of antibody-based approaches for this diagnosis. Novel methods involving immunohistochemistry and immunocapture of defective enzymes for characterization are described that add to the arsenal of approaches available.
Databáze: MEDLINE