| Autor: |
Kim JD; College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea., Kim IS, Jin CH, Zee OP, Jung YH |
| Jazyk: |
angličtina |
| Zdroj: |
Organic letters [Org Lett] 2005 Sep 01; Vol. 7 (18), pp. 4025-8. |
| DOI: |
10.1021/ol0515255 |
| Abstrakt: |
The total synthesis of (-)-cytoxazone 1 was achieved in six linear steps (34% overall yield) from p-anisaldehyde. The key steps in this route are the regioselective and stereoselective introduction of a N-protected amine group, using the CSI reaction of the anti-1,2-dimethyl ether 3, and the subsequent regioselective cyclization of the N-protected amino diol 13 to give the 2-oxazolidinone unit of (-)-cytoxazone 1. [reaction: see text] |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
