| Autor: |
Gilmour G; Eli Lilly and Co. Ltd., Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH, UK. gimour_gary@lilly.com, Iversen SD, O'Neill MF, O'Neill MJ, Ward MA, Bannerman DM |
| Jazyk: |
angličtina |
| Zdroj: |
Behavioural brain research [Behav Brain Res] 2005 Nov 30; Vol. 165 (1), pp. 98-109. Date of Electronic Publication: 2005 Aug 18. |
| DOI: |
10.1016/j.bbr.2005.06.027 |
| Abstrakt: |
This study investigated the effect of amphetamine (AMP) on skilled forelimb use following focal cortical ischaemic lesions in the rat. Unilateral lesions were produced by a novel method of intracortical microinjection of endothelin-1 (ET-1), intended to principally target the forelimb representation zone in primary motor-primary somatosensory cortex. Lesions were placed in the hemisphere contralateral to the preferred limb and produced deficits in skilled forelimb use on two tasks: the paw reach (PR) test and the foot fault (FF) test. Beginning on post-lesion day (D) 2, animals received injections of 2 mg/kg AMP and were injected every third day until D26. Animals were tested both during, and 24 h after, AMP administration. AMP facilitated recovery of skilled forelimb use on the PR test when assessed during drug-free test sessions. No such effect was seen on the FF test. These results demonstrate that sub-acute administration of AMP following a unilateral focal ischaemic lesion of FL can facilitate task-dependent recovery of skilled forelimb use in the rat. They also demonstrate that different behavioural tasks measuring superficially similar behavioural outputs may show different sensitivities to such drug effects. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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Full Text from ScienceDirect