Expression of activated transcription factor nuclear factor-kappaB in periodontally diseased tissues.

Autor: Ambili R; Department of Periodontics, Government Dental College, Thiruvananthapuram, Kerala State 695011, India. ambiliranjith@yahoo.com, Santhi WS, Janam P, Nandakumar K, Pillai MR
Jazyk: angličtina
Zdroj: Journal of periodontology [J Periodontol] 2005 Jul; Vol. 76 (7), pp. 1148-53.
DOI: 10.1902/jop.2005.76.7.1148
Abstrakt: Background: Chronic periodontitis is an inflammatory disease found mainly in adults. Little is known about molecular level changes associated with host response in this condition. Nuclear factor-kappaB (NF-kappaB) is a transcription factor implicated in immune and inflammatory responses. NF-kappaB activation has also been reported to be associated with many chronic inflammatory diseases. The purpose of this paper was to compare the nuclear and cytoplasmic expression of NF-kappaB transcription factor (p50/p65) and cytoplasmic expression of IkappaB in periodontal tissues of periodontitis patients and controls.
Methods: Twenty patients with chronic periodontitis and 20 healthy controls were included in the study. Gingival tissues taken during extraction were processed for immunohistochemical staining and evaluation.
Results: Nuclear (activated) p50 was found in 90% of periodontal patient tissues compared to only 30% of healthy tissues. A more significant result was obtained with p65 (75% versus 5%). Intense cytoplasmic immunoreactivity was also observed in periodontitis tissues. IkappaB, the inhibitor of NF-kappaB, was expressed only in 5% of periodontally diseased tissues.
Conclusion: Activation of NF-kappaB (p50/p65) is significant in periodontally diseased tissues, suggesting the potential of inhibitors of NF-kappaB in managing periodontitis.
Databáze: MEDLINE
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