| Autor: |
Bashkatova V; Department of Neurochemical Pharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, 8 Baltiyskaya Street, 125315 Moscow, Russia., Meunier J, Maurice T, Vanin A |
| Jazyk: |
angličtina |
| Zdroj: |
Neuroreport [Neuroreport] 2005 Aug 01; Vol. 16 (11), pp. 1217-21. |
| DOI: |
10.1097/00001756-200508010-00017 |
| Abstrakt: |
We examined whether significant oxidative stress is induced in the brain of juvenile rats exposed in utero to cocaine, and contributes to their mnesic difficulties. We measured nitric oxide generation, using electron paramagnetic resonance, and the thiobarbituric acid reactive species as specific indexes of lipid peroxidation. Both nitric oxide and lipid peroxidation were elevated in the hippocampus of in-utero cocaine-exposed rats as compared with control animals. In-utero cocaine-exposed rats developed significant learning impairments in the water-maze, shown by probe test retrieval deficits. In parallel, behavioural sessions resulted in increases of thiobarbituric acid reactive species levels only in control animals. Therefore, in-utero cocaine exposure resulted in a significant oxidative stress in basal conditions, which may be related to impaired learning ability. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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