Serum lipids in women on oral contraceptives in Zaria-Nigeria.
| Autor: | Yahaya IA; Department of Chemical Pathology, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria., Afonja OA |
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| Jazyk: | angličtina |
| Zdroj: | The Nigerian postgraduate medical journal [Niger Postgrad Med J] 2005 Jun; Vol. 12 (2), pp. 85-8. |
| Abstrakt: | Aim: To compare the serum lipid levels of women on two different types of oral contraceptives, norethindrone 0.5 mg/ethinyl oestradiol 0.035 mg and norgesterol 0.5 mg/ethinyl oestradiol 0.03 mg. Method: Serum total cholesterol, HDL-cholesterol, LDL-cholesterol and triglyceride levels were estimated in two groups (A&B) of women. Group A were 35 women who had been on norethindrone 0.5 mg/ethinyl oestradiol 0.035 mg for over one year, while the group B were 35 women on norgesterol 0.5 mg/ethinyl oestradiol 0.03 mg for three months. Thirty five healthy, age- matched women not on oral contraceptive agent were used as controls. Results: Significantly higher levels of serum total cholesterol and triglycerides were found in the group A women compared to the group B women. The mean HDL-cholesterol level was significantly higher in the group B women in the 2nd and 3rd months of therapy than in the controls. The LDL-cholesterol levels were statistically similar in the two groups of contraceptive users and the controls. The results obtained were within the reference interval established in our laboratory. Conclusion: The oral contraceptive containing norgesterol 0.5 mg/ethinyl oestradiol 0.03 mg was found to be better as it increased the levels of HDL-cholesterol more than the other lipids. It is not known if this finding will persist on long-term use of the oral contraceptive. |
| Databáze: | MEDLINE |
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