| Autor: |
Yan Z; Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA., Cui K, Murray DM, Ling C, Xue Y, Gerstein A, Parsons R, Zhao K, Wang W |
| Jazyk: |
angličtina |
| Zdroj: |
Genes & development [Genes Dev] 2005 Jul 15; Vol. 19 (14), pp. 1662-7. Date of Electronic Publication: 2005 Jun 28. |
| DOI: |
10.1101/gad.1323805 |
| Abstrakt: |
PBAF and BAF are two chromatin-remodeling complexes of the SWI/SNF family essential for mammalian transcription and development. Although these complexes share eight identical subunits, only PBAF can facilitate transcriptional activation by nuclear receptors in vitro. Here we show that these complexes have selectivity in mediating transcription of different interferon-responsive genes. The selectivity by PBAF requires a novel subunit, BAF200, but not the previously described PBAF-specificity subunit, BAF180 (Polybromo). Our study provides in vivo evidence that PBAF and BAF regulate expression of distinct genes, and suggests that BAF200 plays a key role in PBAF function. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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