Severe thrombocytopenia after heparin therapy in a patient with unstable angina and recent stent implantation.

Autor: Sideris SK; Department of Cardiology, General Hospital of Karditsa, Greece. skevos1@otenet.gr, Bonios MJ, Eftihiadis EE, Melexopoulou CA, Mousiama TA, Diplaris KT, Kogias JS
Jazyk: angličtina
Zdroj: Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese [Hellenic J Cardiol] 2005 May-Jun; Vol. 46 (3), pp. 242-6.
Abstrakt: Heparin-induced thrombocytopenia represents a serious side effect of heparin therapy. Immune-mediated platelet activation results in thrombocytopenia, endothelial thrombin release and development of thrombosis, mainly venous. We report the case of a man with a history of coronary artery disease and recent stent implantation. This patient developed severe heparin-induced thrombocytopenia type II after low molecular weight heparin administration because of unstable angina which occurred two months after stent implantation. The patient was treated with a new anticoagulant regimen, fondaparinux sodium. There were no complications and platelet counts were restored to normal levels.
Databáze: MEDLINE