| Autor: |
Campino S; Instituto Gulbenkian de Ciência, Oeiras, Portugal., Bagot S, Bergman ML, Almeida P, Sepúlveda N, Pied S, Penha-Gonçalves C, Holmberg D, Cazenave PA |
| Jazyk: |
angličtina |
| Zdroj: |
Genes and immunity [Genes Immun] 2005 Aug; Vol. 6 (5), pp. 416-21. |
| DOI: |
10.1038/sj.gene.6364219 |
| Abstrakt: |
Unprecedented cure after infection with the lethal Plasmodium berghei ANKA was observed in an F2 progeny generated by intercrossing the wild-derived WLA and the laboratory C57BL/6 mouse strains. Resistant mice were able to clear parasitaemia and establish immunity. The observed resistance was disclosed as a combinatorial effect of genetic factors derived from the two parental strains. Genetic mapping of survival time showed that the WLA allele at a locus on chromosome 1 (colocalizing with Berghei resistance 1 (Berr1), a locus associated with resistance to experimental cerebral malaria) increases the probability to resist early death. Also, the C57Bl/6 allele at a novel locus on chromosome 9 (Berr3) confers overall resistance to this lethal Plasmodium infection. This report underlines the value of using wild-derived mouse strains to identify novel genetic factors in the aetiology of disease phenotypes, and provides a unique model for studying parasite clearance and immunity associated with malaria. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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