| Autor: |
Sirachainan E; Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand., Sumboonnanonda K, Dangprasert S, Panvichian R, Sirisinha T, Dhanachai M, Pairachvet V, Kraiphibul P, Ratanatharathorn V |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the Medical Association of Thailand = Chotmaihet thangphaet [J Med Assoc Thai] 2005 Feb; Vol. 88 (2), pp. 162-7. |
| Abstrakt: |
A retrospective study of the preoperative chemoradiotherapy in locally advanced rectal cancer performed at Ramathibodi Hospital. The median age of twelve patients was 52 years. The tumor locations (upper-, mid-, lower rectum) were 25%, 50% and 25%, respectively. Eleven patients had clinical stage 111 disease. All received concurrent 5-FU-based chemoradiotherapy followed by surgery (if resectable) and chemotherapy. The most common toxicity of preoperative treatment was gr. 1-2 diarrhea (58.3%). The response rate was 41.7%. Five patients (41.7%) underwent sphincter-sparing surgery. Four patients underwent AP resection. Twenty-five percent achieved pathological complete response. Pathological downstaging occurred in 33.3%. The remaining three patients had unresectable disease. With the median follow up of 13 months, five patients had progressive disease and one has expired. The local failure rate was 16.7%. The one-year recurrence-free survival was 75%. The authors conclude that preoperative chemoradiotherapy is an effective treatment with favorable outcome in locally advanced rectal cancer. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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