Childhood craniopharyngioma: Vancouver experience.

Autor: Hukin J; Division of Neurology and Oncology, British Columbia Children's Hospital, 4480 Oak St., Vancouver, V6H 3V4, Canada. jhukin@cw.bc.ca, Visser J, Sargent M, Goddard K, Fryer C, Steinbok P
Jazyk: angličtina
Zdroj: Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery [Childs Nerv Syst] 2005 Aug; Vol. 21 (8-9), pp. 758-65. Date of Electronic Publication: 2005 Jun 14.
DOI: 10.1007/s00381-005-1220-7
Abstrakt: Objective: To present our institution's experience in the management of childhood craniopharyngioma since 1982.
Methods: We retrospectively reviewed the records of all children diagnosed with craniopharyngioma at our children's hospital from its opening in 1982 through to 2003. One neuroradiologist systematically reviewed the neuroimaging. Kaplan-Meier curves were used to analyze the progression-free survival and the overall survival from the time of the first definitive intervention.
Conclusions: Most children diagnosed with craniopharyngioma are long-term survivors. Survivors suffer from multiple deficits in the long term. A conservative surgical and radiotherapeutic approach and avoiding interventions that are known to cause severe morbidity may minimize these. The use of intracystic bleomycin is a strategy that allows the delay of more aggressive therapies in select patients.
Databáze: MEDLINE
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