Practical synthesis of (Z)-polyaromatic and heteroaromatic vinylacetylenes.
| Autor: | Hayford A; Department of Chemistry, Thomas Harriot College of Arts and Sciences, East Carolina University, Science and Technology Building, Suite 300, Greenville, North Carolina 27858-4343, USA. hayforda@mail.ecu.edu, Kaloko J Jr, El-Kazaz S, Bass G, Harrison C, Corprew T |
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| Jazyk: | angličtina |
| Zdroj: | Organic letters [Org Lett] 2005 Jun 23; Vol. 7 (13), pp. 2671-3. |
| DOI: | 10.1021/ol0508173 |
| Abstrakt: | [reaction: seet text] Two synthetic routes to several (Z)-polyaromatic and heteroaromatic substituted vinylacetylenes are described. The nature of aryl- or heteroaryl-substituted carboxaldehyde used as starting material dictated the choice of Wittig salt employed. A very attractive way to construct polyaromatic and pyridine-containing enynes is the reaction of polyaromatic and pyridine-containing aldehydes with bromomethyltriphenylphosphonium bromide in the presence of potassium tert-butoxide followed by a Sonogashira desilylation procedure (method B). |
| Databáze: | MEDLINE |
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