| Autor: |
Poon AP; The Marjorie B. Kovler Viral Oncology Laboratories, The University of Chicago, 910 East 58th Street, Chicago Illinois 60637, USA., Roizman B |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of virology [J Virol] 2005 Jul; Vol. 79 (13), pp. 8470-9. |
| DOI: |
10.1128/JVI.79.13.8470-8479.2005 |
| Abstrakt: |
The U(S)3 open reading frame of herpes simplex virus 1 (HSV-1) was reported to encode two mRNAs each directing the synthesis of the same protein. We report that the U(S)3 gene encodes two proteins. The predominant U(S)3 protein is made in wild-type HSV-1-infected cells. The truncated mRNA and a truncated protein designated U(S)3.5 and initiating from methionine 77 were preeminent in cells infected with a mutant lacking the gene encoding ICP22. Both the wild-type and truncated proteins also accumulated in cells transduced with a baculovirus carrying the entire U(S)3 open reading frame. The U(S)3.5 protein accumulating in cells infected with the mutant lacking the gene encoding ICP22 mediated the phosphorylation of histone deacetylase 1, a function of U(S)3 protein, but failed to block apoptosis of the infected cells. The U(S)3.5 and U(S)3 proteins differ with respect to the range of functions they exhibit. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
