New two-amino acid insertion near codon 70 of the HIV type 1 protease gene.

Autor: Winters MA; Division of Infectious Diseases, Stanford University Medical Center, Stanford, California 94305, USA. mark.winters@stanford.edu, Kagan RM, Heseltine PN, Merigan TC
Jazyk: angličtina
Zdroj: AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2005 Apr; Vol. 21 (4), pp. 311-3.
DOI: 10.1089/aid.2005.21.311
Abstrakt: A two-amino acid insertion near codon 70 of the HIV-1 protease gene was found in an individual failing protease inhibitor therapy. Susceptibility of this strain to protease inhibitors was similar to that of non-insert-containing strains with comparable resistance mutations and one or more other major PI mutations.
Databáze: MEDLINE