Hyperoxia with 100% oxygen following hypoxia-ischemia increases brain damage in newborn rats.
| Autor: | Shimabuku R; Instituto Especializado de Salud del Niño, Lima, Peru. shimabuku@viabcp.com, Ota A, Pereyra S, Véliz B, Paz E, Nakachi G, More M, Oliveros M |
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| Jazyk: | angličtina |
| Zdroj: | Biology of the neonate [Biol Neonate] 2005; Vol. 88 (3), pp. 168-71. Date of Electronic Publication: 2005 Jun 03. |
| DOI: | 10.1159/000086206 |
| Abstrakt: | Objective: To describe the effect of reoxygenation with 100% O2 as compared to the effect of room air in newborn rat brains after asphyxia. Methods: Experimental asphyxia (carotid artery ligation followed by hypoxic exposure with 8% O2 for 2 h) was performed on 7-day-old rats. After hypoxia-ischemia the rats were reoxygenated with either 100% O2 (hyperoxia group) or 21% O2 (room air group) for 24 h and then returned to the dam. The rats were killed 1 week after the experiment to study the cerebral cortex and hippocampus. Results: Rats reoxygenated with 100% O2 post-asphyxia showed more frequency of cortical damage (10 of 24 rats) than those reoxy genated with room air (3 of 24 rats) (chi2 test, p = 0.02). Conclusion: We consider that hyperoxia with 100% oxygen after hypoxia-ischemia can cause more damage in the cerebral cortex than room air in newborn rats. |
| Databáze: | MEDLINE |
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