High levels of hydrogen peroxide in overnight tooth-whitening formulas: effects on enamel and pulp.

Autor: Pugh G Jr; Colgate-Palmolive Company, Piscataway, NJ, USA. George_Pugh_Jr@colpal.com, Zaidel L, Lin N, Stranick M, Bagley D
Jazyk: angličtina
Zdroj: Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] [J Esthet Restor Dent] 2005; Vol. 17 (1), pp. 40-5; discussion 46-7.
DOI: 10.1111/j.1708-8240.2005.tb00082.x
Abstrakt: Purpose: Limited data are available to assess the safety of high levels of hydrogen peroxide in overnight tooth-whitening formulas. The purpose of this study was to assess the effects of hydrogen peroxide on enamel microhardness, pulp penetration, and enamel morphology.
Materials and Methods: Colgate Platinum Professional Overnight Whitening System (Colgate Oral Pharmaceuticals, Inc., Canton, MA, USA) (10% carbamide peroxide, equivalent to 3.5% hydrogen peroxide) was compared with two prototype formulations containing either 7.0% or 12.0% hydrogen peroxide. In the pulp chamber studies, human extracted teeth were exposed to 3.5%, 7.0%, or 12.0% hydrogen peroxide for 30 minutes, 4 hours, or 7 hours. Microhardness, electron spectroscopy for chemical analysis, and atomic force microscopy evaluations were made from enamel blocks cut from human extracted molars. The enamel blocks were evaluated following 14 7-hour treatments (98 h total).
Results: At 7 hours' post-treatment, hydrogen peroxide penetrated the pulp chamber at 23.12 +/- 10.09, 24.58 +/- 6.90, and 26.39 +/- 5.43 microg for 3.5%, 7.0%, and 12.0% hydrogen peroxide, respectively. With regard to enamel morphology, pulp penetration, microhardness, and elemental composition, no statistically significant differences were observed between treatment groups following 98 hours of treatment.
Conclusions: Hydrogen peroxide does not adversely affect enamel morphology or microhardness. The levels recovered in pulp indicate that hydrogen peroxide is not expected to inhibit pulpal enzymes.
Clinical Significance: Overnight tray products containing levels of hydrogen peroxide of 3.5%, 7.0%, and 12.0% are not expected to adversely affect the enamel or pulpal enzymes. Additional safety studies are needed to assess the potential for tooth sensitivity and gingival irritation.
Databáze: MEDLINE
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