Ocular hypertensive and anti-inflammatory responses to different dosages of topical dexamethasone in children: a randomized trial.
| Autor: | Lam DS; Department of Ophthalmology and Visual Sciences, Hong Kong Eye Hospital, Chinese University of Hong Kong, Kowloon, Hong Kong. dennislam_pub@cuhk.edu.hk, Fan DS, Ng JS, Yu CB, Wong CY, Cheung AY |
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| Jazyk: | angličtina |
| Zdroj: | Clinical & experimental ophthalmology [Clin Exp Ophthalmol] 2005 Jun; Vol. 33 (3), pp. 252-8. |
| DOI: | 10.1111/j.1442-9071.2005.01022.x |
| Abstrakt: | Background: The purpose of the present study was to investigate the ocular hypertensive and anti-inflammatory responses to two different dosage schedules of 0.1% topical dexamethasone in a population of Chinese children undergoing strabismus surgery. Methods: Children undergoing bilateral strabismus surgeries were randomly assigned to receive topical 0.1% dexamethasone eye drops four times daily (group A) or twice daily (group B) for 4 weeks. Intraocular pressure (IOP) and anti-inflammatory responses were monitored for 8 weeks. Results: A total of 137 children with mean age 6.5 years (SD, 1.9 years; range, 3-10 years) participated in the study. The IOP increased significantly after 4 weeks in both groups compared to the preoperative values (P < 0.001). Peak IOP ranged from 14.0 to 50.3 mmHg in group A and 11.0-41.3 mmHg in group B. Cases in group A (mean, 13.8 mmHg; SD, 8.4 mmHg) had a greater net increase in IOP than cases in group B (mean, 10.2 mmHg; SD, 6.2 mmHg; P = 0.004). Younger-aged children had higher peak IOP (r = -0.244, P = 0.048), and attained the peak IOP earlier (r = 0.252, P = 0.041) in group A. There was no significant difference in ocular inflammatory response between the two groups. Conclusion: Ocular hypertensive effect to topical 0.1% dexamethasone is dose and age dependent in children. Twice-daily 0.1% topical dexamethasone eye drops control inflammation after strabismus surgery as effectively as four-times-daily dosage, but induces less increase in IOP, and may be a better treatment schedule. |
| Databáze: | MEDLINE |
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