| Autor: |
LePla RC; Department of Chemistry, University of Warwick, Coventry, UK., Landreau CA, Shipman M, Hartley JA, Jones GD |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2005 Jun 02; Vol. 15 (11), pp. 2861-4. Date of Electronic Publication: 2005 Apr 25. |
| DOI: |
10.1016/j.bmcl.2005.03.091 |
| Abstrakt: |
A series of bisepoxides based on the epoxide domain of the naturally occurring azinomycins have been synthesised. The incorporation of an aminomethyl group into the linker between the two alkylating epoxide units is shown to significantly enhance in vitro cytotoxicity against human tumour cell lines and DNA interstand cross-linking efficiency. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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