| Autor: |
Bernal-Redondo R; Laboratory of Parasitology and Mycology, Children's Hospital of Mexico Federico Gómez, Mexico DF, Mexico. bernalhim@yahoo.com.mx, Martínez-Méndez LG, Mendoza-Chavez A, Velasco-Perales D, Chavez-Munguia B |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of submicroscopic cytology and pathology [J Submicrosc Cytol Pathol] 2004 Jul-Oct; Vol. 36 (3-4), pp. 241-5. |
| Abstrakt: |
Effect of albendazole, metronidazole and nitazoxanide on the viability and structure of Giardia lamblia cysts isolates from infected children. The viability was evaluated by inducing excystation in a low-pH solution followed by an incubation in TYI-S culture medium. Nitazoxanide exhibited potent inhibitory effect (100%), metronidazole (79%) and albendazole (31%). The analysis among groups indicated a rs = 0.75 and p < 0.05. By TEM the cysts incubated with albendazole did not show morphological changes; with metronidazole, the formation of residual bodies in the nucleus border was observed. Incubated with nitazoxanide the damage to the cyst wall was evident, with the formation of areas with a granular content and the presence of cytoplasmic components in the peritrophic space. Our results propose that nitazoxanide showed a high effect on the viability and structure of G. lamblia cysts. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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