| Autor: |
Roulland E; Laboratoire de Chimie Thérapeutique, UMR 8638 associée au CNRS et à l'Université René Descartes (Paris 5), Faculté des Sciences Pharmaceutiques et Biologiques, 4 Avenue de l'Observatoire, 75270 Paris Cedex 06, France., Cecchin F, Husson HP |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of organic chemistry [J Org Chem] 2005 May 27; Vol. 70 (11), pp. 4474-7. |
| DOI: |
10.1021/jo050258d |
| Abstrakt: |
A methodology allowing the construction of spiropiperidine scaffolds similar to those found in naturally occurring alkaloids has been developed. This approach begins with the well-established CN(R,S) strategy, the spiro-center being built by way of an intramolecular attack of a nitrile function by an organolithium species obtained by a halogen/lithium exchange reaction mediated by either t-BuLi or lithium naphthalenide. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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