[Current status of the prognostic value of molecular markers in patients with colorectal cancer and the prediction of response to adjuvant therapy].

Autor: Fernández-Cebrián JM; Unidad de Cirugía General y Aparato Digestivo, Fundación Hospital Alcorcón, C/Budapest 1, Alcorcón, 28922 Madrid, Spain. jmfernandez@fhalcoron.es, Vorwald Kuborn P, Pardo de Lama M, Sanjuanbenito Dehesa A, Nevado Santos M, Pacheco Martínez PA, Fernández-Escudero B
Jazyk: Spanish; Castilian
Zdroj: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico [Clin Transl Oncol] 2005 Apr; Vol. 7 (3), pp. 101-9.
DOI: 10.1007/BF02708742
Abstrakt: Colorectal cancer is one of the best studied of all malignant diseases in terms of genetics and/or molecular prognostic factors. These factors, and relationships with prognosis, may have important implications especially in the design of surgical and adjuvant chemo-radiotherapy options. However, the true prognostic significance of all known factors has yet to be realised. We have reviewed the literature with specific focus on the role of molecular markers involved in prognosis and the prediction of response to adjuvant treatment.
Databáze: MEDLINE