Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers effectively and directly potentiate superoxide scavenging by polymorphonuclear leukocytes from patients with type 2 diabetes mellitus.

Autor: Inukai T; Department of Internal Medicine, Koshigaya Hospital, Dokkyo University School of Medicine, Saitama, Japan. t-inukai@dokkyomed.ac.jp, Yoshida N, Wakabayashi S, Inukai Y, Matsutomo R, Takanashi K, Nakamachi T, Takebayashi K, Aso Y, Takahashi K
Jazyk: angličtina
Zdroj: The American journal of the medical sciences [Am J Med Sci] 2005 May; Vol. 329 (5), pp. 222-7.
DOI: 10.1097/00000441-200505000-00002
Abstrakt: Background: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs) have potent antioxidant effects in addition to antihypertensive effects.
Methods: We investigated the ability of ACEIs and ARBs to enhance the superoxide scavenging ability of polymorphonuclear leukocytes (PMNLs) from type 2 diabetic patients (n = 32) and healthy subjects (n = 32). The scavenging ability (U/10(3) cells) of superoxide was measured by electron spin resonance. We used ascorbic acid as a positive control antioxidant and tested captopril, temocapril (an inactive form of ACEI), and temocaprilate (an active form of ACEI) as ACEIs, as well as RNH-6270 as an ARB.
Results: Captopril, temocaprilate, and RNH-6270 showed dose-dependent enhancement in scavenging ability. The scavenging ability with captopril and temocaprilate was greater than with RNH-6270. The changes in scavenging ability induced by all of the drugs in diabetic patients were similar to the changes in healthy subjects. A high-glucose medium (400-800 mg/dL) greatly attenuated the drug-induced enhancement of scavenging ability.
Conclusions: We demonstrated that both ACEIs and ARBs enhance superoxide scavenging by PMNLs from type 2 diabetic patients and that a high-glucose environment markedly attenuates the ability of these drugs to augment superoxide scavenging.
Databáze: MEDLINE
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