| Autor: |
Kustanovich AM; Laboratory of Molecular Biology, Belarussian Research Center for Pediatric Oncology and Hematology, P.O. Lesnoye, Minsk 223040, Belarus. akustanovich@tut.by, Savitskaja TV, Bydanov OI, Belevtsev MV, Potapnev MP |
| Jazyk: |
angličtina |
| Zdroj: |
Leukemia research [Leuk Res] 2005 Nov; Vol. 29 (11), pp. 1271-6. |
| DOI: |
10.1016/j.leukres.2005.04.006 |
| Abstrakt: |
Aberrant expression of tumor suppressor genes WT 1, RB 1, p53, homozygous deletion of p16 gene and their relationship with expression of oncogenes BCR-ABL, TEL-AML 1, MLL-AF 4, E2A-PBX 1, SIL-TAL 1 were determined in bone marrow samples of children with de novo B-lineage (n=170) and T-lineage (n=25) acute lymphoblastic leukemia (ALL). In contrast to expression of chimeric oncogenes alterations in p16, WT 1, RB 1 and p53 expression were T/B-lineage-unrestricted. Significant association between expression of MLL-AF 4 and WT 1, E2A-PBX 1 and p53; SIL-TAL 1 and homozygous deletion of p16 has been demonstrated. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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