| Autor: |
Shankarkumar U; Institute of Immunohaematology (ICMR), 13th Floor, K.E.M. Hospital, Parel, Mumbai 400012, Maharashtra, India. shankarkumar16@hotmail.com, Ghosh K, Pradhan VD, Badakere SS, Mohanty D |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of autoimmunity [J Autoimmun] 2005 May; Vol. 24 (3), pp. 227-33. |
| DOI: |
10.1016/j.jaut.2005.01.009 |
| Abstrakt: |
Considerable genetic evidence exit for ANCA-associated vasculitis and pathogenesis. HLA A and B alleles identified serologically from 84 ANCA-positive patients were compared with 101 controls. Further subtyping were done in the 27 "pauci-immune" vasculitis patients using the polymerase chain reaction based PCR-SSOP technique and compared with controls (67). The results revealed that HLA A1 (OR=4.00; p value 2.72E-05), B17 (OR=3.38; p value 0.0008) and HLA B40 (OR=2.74; p value 0.001) were significantly increased among ANCA-positive patients when compared with the controls. Further, the molecular subtypes A*0101 (OR=5.04; p value 0.0005), B*5801 (OR=4.47; p value 0.0002) and haplotype A*0101-B*5801 (OR=4.47; p value 0.0001) were significantly increased among the autoimmune patients. The study revealed that HLA A1, B17 and B40 alleles are associated in production of antineutrophil autoantibodies and A*0101-B*5801 haplotype is significantly associated with autoimmune diseases and they may be invariably involved in disease pathogenesis in India. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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