Use of long-acting tetracyclines for methicillin-resistant Staphylococcus aureus infections: case series and review of the literature.

Autor:	Ruhe JJ; Division of Infectious Diseases, Department of Medicine, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA. ruhejorgj@uams.edu, Monson T, Bradsher RW, Menon A
Jazyk:	angličtina
Zdroj:	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2005 May 15; Vol. 40 (10), pp. 1429-34. Date of Electronic Publication: 2005 Apr 06.
DOI:	10.1086/429628
Abstrakt:	Background: Few data exist on the efficacy of the long-acting tetracyclines doxycycline and minocycline against methicillin-resistant Staphylococcus aureus (MRSA) infection. Methods: The medical records of 24 patients with serious tetracycline-susceptible MRSA infections who were treated with doxycycline or minocycline were reviewed. A review of the literature on the use of these antibiotics for treatment of both methicillin-susceptible and methicillin-resistant S. aureus infection was also performed. Results: Complicated skin and skin-structure infections were most common (67%). Clinical cure was achieved in 20 (83%) of 24 patients in our case series. Both drugs were well-tolerated. The review of the literature on a total of 85 patients with S. aureus infection revealed similar results. Conclusions: Long-acting tetracyclines may be a reasonable treatment alternative for patients with certain types of MRSA infection.
Databáze:	MEDLINE
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