Molecular action of 1,25-dihydroxyvitamin D3 and phorbol ester on the activation of the rat cytochrome P450C24 (CYP24) promoter: role of MAP kinase activities and identification of an important transcription factor binding site.
| References: | J Biol Chem. 2003 Sep 5;278(36):34709-16. (PMID: 12794082) Mol Endocrinol. 2003 May;17(5):777-91. (PMID: 12637589) Endocr Res. 2003 Nov;29(4):457-64. (PMID: 14682474) Am J Physiol Endocrinol Metab. 2004 Apr;286(4):E598-608. (PMID: 14665442) Curr Opin Neurobiol. 2004 Jun;14(3):328-40. (PMID: 15194113) J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):233-8. (PMID: 15225777) Proc Natl Acad Sci U S A. 1986 Jan;83(2):241-5. (PMID: 3079908) Biochem Biophys Res Commun. 1989 Mar 15;159(2):548-53. (PMID: 2467670) Cancer Res. 1991 Feb 1;51(3):850-6. (PMID: 1899047) Nucleic Acids Res. 1991 May 11;19(9):2499. (PMID: 2041787) J Biol Chem. 1991 Aug 25;266(24):15771-81. (PMID: 1874734) Endocrinology. 1993 Apr;132(4):1782-8. (PMID: 7681765) FEBS Lett. 1993 Jul 19;327(1):13-6. (PMID: 8335088) Annu Rev Neurosci. 1994;17:551-67. (PMID: 8210187) Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6030-4. (PMID: 8016110) J Cell Biochem. 1994 Jun;55(2):230-40. (PMID: 8089198) J Biol Chem. 1995 Jan 27;270(4):1675-8. (PMID: 7829502) J Biol Chem. 1995 Mar 3;270(9):4201-4. (PMID: 7876176) Mol Endocrinol. 1996 Jul;10(7):781-93. (PMID: 8813719) J Biol Chem. 1996 Nov 22;271(47):29715-21. (PMID: 8939905) J Biol Chem. 1996 Nov 29;271(48):30381-5. (PMID: 8940000) J Biol Chem. 1997 Feb 14;272(7):4219-24. (PMID: 9020136) J Biol Chem. 1998 Jul 24;273(30):19277-82. (PMID: 9668117) J Mol Endocrinol. 1998 Jun;20(3):327-35. (PMID: 9687155) Physiol Rev. 1998 Oct;78(4):1193-231. (PMID: 9790574) J Immunol. 1999 Jan 1;162(1):415-22. (PMID: 9886415) Bone. 1999 Jul;25(1):127-9. (PMID: 10423037) J Biol Chem. 1951 Nov;193(1):265-75. (PMID: 14907713) Physiol Rev. 2001 Jan;81(1):239-297. (PMID: 11152759) Steroids. 2001 Mar-May;66(3-5):381-9. (PMID: 11179747) J Endocrinol. 2001 Apr;169(1):145-51. (PMID: 11250655) J Biol Chem. 2001 Jul 20;276(29):27246-55. (PMID: 11359783) Vitam Horm. 2002;64:357-406. (PMID: 11898396) Mol Cell Endocrinol. 2002 Feb 25;188(1-2):227-39. (PMID: 11911960) J Biol Chem. 2002 Apr 12;277(15):12532-40. (PMID: 11812784) Biol Reprod. 2002 Jun;66(6):1656-66. (PMID: 12021044) Annu Rev Nutr. 2002;22:139-66. (PMID: 12055341) J Biol Chem. 2002 Aug 16;277(33):29643-53. (PMID: 12048211) J Cell Biochem. 2003 Feb 1;88(2):296-307. (PMID: 12520530) J Biol Chem. 2003 Jan 24;278(4):2199-205. (PMID: 12417593) Eur J Endocrinol. 2003 Mar;148(3):281-92. (PMID: 12611608) J Biol Chem. 1999 Dec 10;274(50):35505-13. (PMID: 10585423) J Biol Chem. 2000 Jan 7;275(1):47-55. (PMID: 10617584) Gene. 2000 Apr 4;246(1-2):9-21. (PMID: 10767523) Int J Biochem Cell Biol. 2000 Jun;32(6):581-7. (PMID: 10785355) Endocrinology. 2000 Jul;141(7):2658-66. (PMID: 10875271) FASEB J. 2000 Jul;14(10):1455-63. (PMID: 10877839) J Mol Endocrinol. 2000 Oct;25(2):141-8. (PMID: 11013342) Pharmacol Rev. 2000 Dec;52(4):513-56. (PMID: 11121509) J Biol Chem. 2003 Mar 7;278(10):8224-8. (PMID: 12529369) J Invest Dermatol. 2003 Apr;120(4):561-70. (PMID: 12648218) Annu Rev Nutr. 2003;23:117-45. (PMID: 12651965) |
|---|---|
| Substance Nomenclature: | 0 (Transcription Factors) EC 1.14.- (Steroid Hydroxylases) EC 1.14.15.16 (Vitamin D3 24-Hydroxylase) EC 2.7.11.13 (Protein Kinase C) EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases) EC 2.7.11.24 (Mitogen-Activated Protein Kinases) EC 2.7.12.2 (MAP Kinase Kinase 4) EC 2.7.12.2 (Mitogen-Activated Protein Kinase Kinases) FXC9231JVH (Calcitriol) NI40JAQ945 (Tetradecanoylphorbol Acetate) |
| Entry Date(s): | Date Created: 20050420 Date Completed: 20051104 Latest Revision: 20181113 |
| Update Code: | 20240829 |
| PubMed Central ID: | PMC1180726 |
| DOI: | 10.1042/BJ20041947 |
| PMID: | 15836435 |
| Autor: | Nutchey BK; School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5000, Australia., Kaplan JS, Dwivedi PP, Omdahl JL, Ferrante A, May BK, Hii CS |
| Jazyk: | angličtina |
| Zdroj: | The Biochemical journal [Biochem J] 2005 Aug 01; Vol. 389 (Pt 3), pp. 753-62. |
| DOI: | 10.1042/BJ20041947 |
| Abstrakt: | Although investigations of the transcriptional regulation of the rat cytochrome P450C24 [CYP24 (25-hydroxyvitamin D3 24-hydroxylase)] gene by 1,25D (1,25-dihydroxyvitamin D3) at either the genomic, or more recently at the non-genomic, level have provided insight into the mechanism of control of 1,25D levels, this regulation is still poorly characterized. Using HEK-293T cells (human embryonic kidney 293T cells), we reported that 1,25D induction of CYP24 requires JNK (c-Jun N-terminal kinase) but not the ERK1/2 (extracellular-signal-regulated kinase 1/2). The phenomenon of synergistic up-regulation of CYP24 expression by PMA and 1,25D is well known and was found to be protein kinase C-dependent. Whereas ERK1/2 was not activated by 1,25D alone, its activation by PMA was potentiated by 1,25D also. The importance of ERK1/2 for transcriptional synergy was demonstrated by transfection of a dominant-negative ERK1(K71R) mutant (where K71R stands for Lys71-->Arg), which resulted in a reduced level of synergy on a CYP24 promoter-luciferase construct. JNK was also shown to be required for synergy. We report, in the present study, the identification of a site located at -171/-163, about 30 bp upstream of the vitamin D response element-1 in the CYP24 proximal promoter. This sequence, 5'-TGTCGGTCA-3', is critical for 1,25D induction of CYP24 and is therefore termed the vitamin D stimulatory element. The vitamin D stimulatory element, a target for the JNK module, and an Ets-1 binding site were shown to be vital for synergy between PMA and 1,25D. This is the first report to identify the DNA binding sequences required for the synergy between PMA and 1,25D and a role for JNK on the CYP24 gene promoter. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|