Comparison of enzymatic and microbiological gentamicin assays.

Autor: Smith AL, Waitz JA, Smith DH, Oden EM, Emerson BB
Jazyk: angličtina
Zdroj: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 1974 Sep; Vol. 6 (3), pp. 316-9.
DOI: 10.1128/AAC.6.3.316
Abstrakt: The correlation coefficient between the rapid enzymatic and the overnight microbiological assays for 211 urine and serum specimens was 0.96. The 95% confidence limits yielded a correlation coefficient between 0.92 and 0.98. Both methods tended to underestimate the amount of a gentamicin added to urine. When only serum samples were considered, the predicted value obtained from the linear regression analysis of either method was within 0.57 mug/ml 99% of the time. This high degree of positive correlation will permit safe rapid adjustment of individualized patient gentamicin dosages.
Databáze: MEDLINE