Cytostatics and anastomotic healing in the intestine: an experimental study on the effect of parenteral nutrition.

Autor: de Roy van Zuidewijn DB; Department of General Surgery, St. Radboud University Hospital, Nijmegen, The Netherlands., Hendriks T, Wobbes T, de Man B, de Boer HH
Jazyk: angličtina
Zdroj: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes [Eur Surg Res] 1992; Vol. 24 (2), pp. 103-11.
DOI: 10.1159/000129195
Abstrakt: The effects of parenteral nutrition on the healing of experimental ileal and colonic anastomoses constructed on the 3rd day of a 5-day cytostatics course were investigated. Intravenous saline alone already reduced weight loss induced by cytostatics while parenteral nutrition almost completely prevented postoperative loss of weight. A negative effect of cytostatics on anastomotic bursting strength was found in the ileum 7 days after operation. Parenteral feeding negated this effect but had no positive effect on anastomotic hydroxyproline content. Thus, parenteral nutrition increases the strength of intestinal anastomoses, constructed during a cytostatics regimen, but intravenous saline alone also appears to have a similar effect.
Databáze: MEDLINE