| Autor: |
Ahmadi A; Department of Science, School of Chemistry, Islamic Azad University, Karaj, Iran. abbas_ahmady_3957@yahoo.com, Shafiezadeh M, Fathollahi Y, Darvich MR, Mahmoudi A, Bahmani M, Rahmati B |
| Jazyk: |
angličtina |
| Zdroj: |
Arzneimittel-Forschung [Arzneimittelforschung] 2005; Vol. 55 (3), pp. 172-6. |
| DOI: |
10.1055/s-0031-1296840 |
| Abstrakt: |
Phencyclidine (1-(1-phenylcyclohexyl)piperidine, CAS 956-90-1, PCP) has shown analgesic effects. Some of its derivatives have been synthesized and their biological properties were studied. Since a hydroxyl group has been added to the position 2 of the cyclohexane ring of PCP, this compound would be more hydrophilic than PCP. This compound was synthesized using a different and improved method with a higher yield. Its analgesic effect was studied using the tail-flick test on rats and was compared with that of ketamine (CAS 1867-66-9). The results showed that 2-hydroxyphencyclidine can increase tail-flick latencies as compared to the control group and indicate that the maximum analgesic effect of this compound occurs 2-5 min after its injection while the effect of ketamine is observed 10-25 min after injection. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
