Membrane biocompatibility does not affect whole body protein metabolism during dialysis.
| Autor: | Veeneman JM; Department of Internal Medicine, Division of Nephrology, University Hospital Groningen, NL-9700 RB Groningen, The Netherlands., Kingma HA, Stellaard F, de Jong PE, Reijngoud DJ, Huisman RM |
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| Jazyk: | angličtina |
| Zdroj: | Blood purification [Blood Purif] 2005; Vol. 23 (3), pp. 211-8. Date of Electronic Publication: 2005 Apr 04. |
| DOI: | 10.1159/000084891 |
| Abstrakt: | Background: Protein-calorie malnutrition is present in 30-50% of dialysis patients. The lack of biocompatibility of the dialysis membrane, which results in low-grade inflammation, could be responsible for this malnutrition. We investigated whether protein-energy malnutrition could be partly due to incompatibility of the dialyzer during the dialysis session. Methods: Five patients were dialyzed during 2 periods of 3 weeks (cross-over) with either a single-use low-flux polysulfone or cellulose triacetate (biocompatible) or a single-use cuprophan (bio-incompatible) membrane. As a measure of whole body protein metabolism, a primed constant infusion of L-[1-(13)C]-valine was used during a 4-hour dialysis session. Results: Cuprophan was a more powerful activator of the complement system than other membranes. Protein metabolism parameters during both study protocols were not different and resulted in the same protein balance during polysulfone/cellulose triacetate (-15 +/- 3) and cuprophan (-13 +/- 2 micromol/kg/h) dialysis. Conclusion: In stable hemodialysis patients with no apparent complications, protein metabolism during dialysis is not affected by the compatibility of the dialysis membrane. |
| Databáze: | MEDLINE |
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