| Autor: |
Miller CM; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37235, USA., Carney CK, Schrimpe AC, Wright DW |
| Jazyk: |
angličtina |
| Zdroj: |
Inorganic chemistry [Inorg Chem] 2005 Apr 04; Vol. 44 (7), pp. 2134-6. |
| DOI: |
10.1021/ic048821i |
| Abstrakt: |
beta-Hematin is an important heme metabolite of malarial infection. Its role as an agent mediating the formation of the reactive electrophile 4-hydroxynonenal (HNE) from polyunsaturated fatty acids was investigated. In vitro formation of HNE was found to be facilitated by the presence of hemozoin in a concentration-dependent fashion. The reactivity of HNE derived from reaction with beta-hematin was confirmed through its ability to form protein adducts on myoglobin. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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