[Study on the variation of platelet function in pregnancy induced hypertension and gestational diabetes mellitus].

Autor:	Yin SM; Department of Hematology, Second Affiliated Hospital, Zhongshan University, Guangzhou 510120, China., Li YQ, Xie SF, Ma LP, Wu YD, Nie DN, Feng JH, Xu LZ
Jazyk:	čínština
Zdroj:	Zhonghua fu chan ke za zhi [Zhonghua Fu Chan Ke Za Zhi] 2005 Jan; Vol. 40 (1), pp. 25-8.
Abstrakt:	Objective: To investigate the platelet activity and function in pregnancy induced hypertension (PIH) and gestational diabetes mellitus (GDM). Methods: Twenty-one patients with GDM and 23 patients with PIH in third-trimester were included. Twenty normal pregnant women in third-trimester served as controls. Platelet count (PC), mean platelet volume (MPV) were determined on Cell-DYN 1600 and the expression of CD62P was analyzed on FACSC alibur. Results: (1) PC was (181 +/- 56) x 10(9)/L in PIH, (206 +/- 60) x 10(9)/L in GDM and (229 +/- 56) x 10(9)/L in controls, respectively. PC in PIH was lower than that of controls (P < 0.01), but there was no significant difference between GDM and controls. (2) MPV was (11.2 +/- 2.0) fl in PIH, significantly higher than that of controls (8.7 +/- 1.6) fl (P < 0.001). In GDM, MPV was (9.5 +/- 1.6) fl, without significant difference compared with that of controls. (3) The expression of CD62P increased significantly in PIH compared with controls [CD62P: (42 +/- 13)% vs (26 +/- 7)%, P < 0.001; CD62P(I): 109 +/- 39 vs 75 +/- 13, P < 0.01]. In GDM, the expression of CD62P also increased significantly compared with the normal pregnancy [CD62P(%): (42 +/- 14)% vs (26 +/- 7), P < 0.001; CD62P(I): 100 +/- 42 vs 75 +/- 13, P < 0.05]. (4) All parameters had no significant difference between PIH and GDM. Conclusion: Platelet activity is enhanced in PIH and GDM. It may play an important role in the pathogenesis and development of the two diseases.
Databáze:	MEDLINE
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