| Autor: |
LaFleur AM; Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA., Lukacs NW, Kunkel SL, Matsukawa A |
| Jazyk: |
angličtina |
| Zdroj: |
Mediators of inflammation [Mediators Inflamm] 2004 Dec; Vol. 13 (5-6), pp. 349-55. |
| DOI: |
10.1080/09629350400014172 |
| Abstrakt: |
The aim of this study was to determine the role of CC chemokine CCL6/C10 in acute inflammation. Intraperitoneal injection of thioglycollate increased peritoneal CCL6, which peaked at 4 h and remained elevated at 48 h. Neutralization of CCL6 significantly inhibited the macrophage infiltration (34-48% reduction), but not other cell types, without decreasing the other CC chemokines known to attract monocytes/macrophages. CCL6 was expressed in peripheral eosinophils and elicited macrophages, but not in elicited neutrophils. Peritoneal CCL6 level was not decreased in granulocyte-depleted mice where eosinophil influx was significantly impaired. Thus, CCL6 appears to contribute to the macrophage infiltration that is independent of other CC chemokines. Eosinophils pre-store CCL6, but do not release CCL6 in the peritoneum in this model of inflammation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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