| Autor: |
Lescano SA; Laboratório de Imunopatologia da Esquistossomose (LIM 06) da Universidade de São Paulo, São Paulo, SP. chiong@uol.com.br, Amato Neto V, Chieffi PP, Bezerra RC, Gakiya E, Ferreira CS, Braz LM |
| Jazyk: |
portugalština |
| Zdroj: |
Revista da Sociedade Brasileira de Medicina Tropical [Rev Soc Bras Med Trop] 2004 Nov-Dec; Vol. 37 (6), pp. 460-2. |
| DOI: |
10.1590/s0037-86822004000600006 |
| Abstrakt: |
The efficacy of prolonged administration of azithromycin and pyrimethamine was evaluated in mice experimentally infected with cystogenic strain of Toxoplasma gondii. The animals were intraperitoneally inoculated with one cyst of T. gondii and after 20 days were allocated into four groups: GI, infected without treatment; GII, infected and treated with the association of pyrimethamine (12.5 mg/kg/day) and azithromycin (100 mg/kg/day); GIII, infected and treated with the same dose of pyrimethamine; and GIV, infected and treated in the same way with azithromycin. The oral treatment lasted 120 days, after this period all the animals were sacrificed and the count of cysts in the brain was done. The association of both drugs provided the best results, by diminishing the cyst count in the brain of the animals treated in this way. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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