Does rigid bronchoscopy induce bacterial translocation? An experimental study in rats.
| Autor: | Ozkurt S; Department of Chest Diseases, Pamukkale University School of Medicine, Denizli, Turkey. ozkurtsibel@hotmail.com, Herek O, Atalay H, Kaleli I, Kara CO |
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| Jazyk: | angličtina |
| Zdroj: | Respiration; international review of thoracic diseases [Respiration] 2005 Jan-Feb; Vol. 72 (1), pp. 85-8. |
| DOI: | 10.1159/000083406 |
| Abstrakt: | Background: Although some reports suggest that bronchoscopy induces bacterial translocation (BT), the mechanisms of BT remain unclear. Objective: We aimed to assess whether bronchoscopy or hypoxemia during bronchoscopy is responsible for BT. Methods: We evaluated 24 rats divided into three subgroups: the control group (group 1, n = 8); the rigid bronchoscopy group (group 2, n = 8), and the group receiving bronchoscopy + mechanical ventilation (group 3, n = 8). Oxygen saturation (SaO(2)) was measured during the bronchoscopic procedure. Blood and tissue cultures from mesenteric lymph nodes (MLNs), liver, spleen and cecal contents were obtained 24 h following bronchoscopy. Results: In group 2, SaO(2) was significantly lower than in groups 1 and 3 (p < 0.01). In group 2, BT significantly increased (6/8, 75%; p < 0.01 vs. group 1, and p < 0.05 vs. group 3). The main site of translocation was MLNs (6/8, 75%) in group 2, while BT was detected in only 1 rat in group 3 (1/8, 12.5%). Conclusion: Hypoxemia during rigid bronchoscopy resulted in intestinal mucosal damage in a rat model. Hypoxemia may have been the trigger for BT from the intestine following bronchoscopy. (Copyright (c) 2005 S. Karger AG, Basel.) |
| Databáze: | MEDLINE |
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