| Autor: |
Bonner PC; Malaria Branch, Division of Parasitic Diseases, NCID, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA., Zhou Z, Mirel LB, Ayisi JG, Shi YP, van Eijk AM, Otieno JA, Nahlen BL, Steketee RW, Udhayakumar V |
| Jazyk: |
angličtina |
| Zdroj: |
Clinical and diagnostic laboratory immunology [Clin Diagn Lab Immunol] 2005 Mar; Vol. 12 (3), pp. 375-9. |
| DOI: |
10.1128/CDLI.12.3.375-379.2005 |
| Abstrakt: |
To determine the effect of placental malaria (PM) infection on the development of antibody responses to malaria in infants, we measured immunoglobulin G levels to seven different Plasmodium falciparum epitopes by using plasma samples collected at monthly intervals from infants born to mothers with and without PM. Overall, PM was associated with diminished antibody levels to all of the epitopes tested, especially with infants aged >or=4 to 12 months, and the difference was statistically significant for four of the seven epitopes (P<0.0035). These findings suggest that PM can negatively influence the development of immune responses to malaria in infants. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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