Analgesic and anti-inflammatory activity of the ethanolic extract from Spiranthera odoratissima A. St. Hillaire (Manacá) roots.

Autor: Matos LG; Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brazil., Pontes IS, Tresvenzol LM, Paula JR, Costa EA
Jazyk: angličtina
Zdroj: Phytotherapy research : PTR [Phytother Res] 2004 Dec; Vol. 18 (12), pp. 963-6.
DOI: 10.1002/ptr.1301
Abstrakt: Acetic acid-induced abdominal writhing, the tail flick test and carrageenan-induced peritonitis were used to study the analgesic and anti-inflammatory activity of the crude ethanolic extract from Spiranthera odoratissima roots. Pentobarbital-induced sleeping time was used to study the central depressant effect of the extract. The ethanolic extract caused a dose dependent inhibition of acetic acid-induced abdominal writhing and leukocyte migration, and produced a significant, dose-related increase in the duration of sleep. The results suggest that Spiranthera odoratissima roots contain compounds with anti-inflammatory and central depressant actions.
(2004 John Wiley & Sons, Ltd.)
Databáze: MEDLINE
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