[Effects of p,p'-DDE on intracellular MAPK pathway of rat Sertoli cells in vitro].
| Autor: | Wang C; Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China., Liang J, Wang A, Yang K |
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| Jazyk: | čínština |
| Zdroj: | Wei sheng yan jiu = Journal of hygiene research [Wei Sheng Yan Jiu] 2004 Nov; Vol. 33 (6), pp. 668-70. |
| Abstrakt: | Objective: To study effects of p,p'-DDE on intracellular p-ERK of rat Sertoli cells in vitro. Methods: We cultured Sertoli cells separated from testicular tissue of rats and examined the changes of intracellular p-ERK, using immunohistochemical SABC method. Results: It was showed that intracellular p-ERK increased with the dose of p,p'-DDE and had a dose-dependent trend. Conclusion: The results suggested that p,p'-DDE could result in the phosphorylation of ERK and induce the activation of the downstream road and the transcription and expression of genes. |
| Databáze: | MEDLINE |
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