| Autor: |
Sa Filho DJ; Retrovirology Laboratory, Federal University of São Paulo, SP 0439032, Brazil., Sanabani S, Diaz RS, Munerato P, Brunstein A, Fusuma E, Sabino EC, Janini LM |
| Jazyk: |
angličtina |
| Zdroj: |
AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2005 Feb; Vol. 21 (2), pp. 145-51. |
| DOI: |
10.1089/aid.2005.21.145 |
| Abstrakt: |
Recombination is one of the major mechanisms contributing to human immunodeficiency virus type 1 (HIV-1) variability. Analysis of pol gene sequences of 215 HIV-1 samples from São Paulo, Brazil classified 189 sequences as subtype B (87.9%), 8 sequences as subtype F (3.7%), and 18 sequences (8.4%) as B/F recombinants. After the analysis of the pol gene, a subset of six recombinant samples composed of sequences with a related recombinant pol structure was selected for full-length genome analysis to identify a possible circulating recombinant form. According to full-length genome analysis, recombination was higher in gag, protease, reverse transcriptase, integrase, and vif. Identification of many distinct recombinant forms and the absence of an identifiable HIV-1 circulating recombinant form suggest that a high frequency of dual infections between HIV-1 subtypes B and F is occurring in São Paulo, Brazil. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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