Effect of destruction of gyrus cinguli in rat brain on the development of tolerance to the analgesic effect of morphine and physical dependence on morphine.

Autor: Sudakov SK; National Research Center of Narcology, Russian Ministry of Health and Social Development, Moscow, Russia. s-sudakov@mtu-net.ru, Rusakova IV, Trigub MN, Shakhmatov VY, Kozel AI, Smith GE
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2004 Nov; Vol. 138 (5), pp. 479-81.
DOI: 10.1007/s10517-005-0075-y
Abstrakt: We studied the effect of bilateral laser destruction of rat anterior cingulate gyrus on the analgesic effect of morphine and development of tolerance and physical dependence on morphine. Bilateral laser destruction of the anterior cingulate gyrus did not modulate pain sensitivity, analgesic effect of morphine, and development of morphine tolerance. Destruction of the cingulate gyrus alleviated symptoms of the abstinence syndrome in morphine-dependent animals. We showed that morphine-induced analgesia and morphine tolerance are not associated with activity of the anterior cingulate gyrus. However, this structure plays a key role in the development of physical dependence on morphine and abstinence syndrome.
Databáze: MEDLINE
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