| Autor: |
Hoek RM; Department of Molecular and Cellular Neurobiology, Research Institute Neurosciences, Faculty of Earth and Life Sciences, Vrije Universiteit, Amsterdam, the Netherlands., Li KW, van Minnen J, Lodder JC, de Jong-Brink M, Smit AB, van Kesteren RE |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of neurochemistry [J Neurochem] 2005 Mar; Vol. 92 (5), pp. 1073-80. |
| DOI: |
10.1111/j.1471-4159.2004.02927.x |
| Abstrakt: |
We report the characterization of a cDNA encoding a novel -RFamide neuropeptide precursor that is up-regulated during parasitation in the snail Lymnaea stagnalis. Processing of this precursor yields five structurally related neuropeptides, all but one ending with the C-terminal sequence -LFRFamide, as was confirmed by direct mass spectrometry of brain tissue. The LFRFamide gene is expressed in a small cluster of neurons in each buccal ganglion, three small clusters in each cerebral ganglion, and one cluster in each lateral lobe of the cerebral ganglia. Application of two of the LFRFamide peptides to neuroendocrine cells that control either growth and metabolism or reproduction induced similar hyperpolarizing K+-currents, and inhibited electrical activity. We conclude that up-regulation of inhibitory LFRFamide neuropeptides during parasitation probably reflects an evolutionary adaptation that allows endoparasites to suppress host metabolism and reproduction in order to fully exploit host energy recourses. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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