| Autor: |
Luca ME; Division of Biomedical Research, TNO Prevention and Health, Zernikedreef 9, 2333 CK Leiden, The Netherlands., Kel JM, van Rijs W, Wouter Drijfhout J, Koning F, Nagelkerken L |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of neuroimmunology [J Neuroimmunol] 2005 Mar; Vol. 160 (1-2), pp. 178-87. Date of Electronic Publication: 2005 Jan 25. |
| DOI: |
10.1016/j.jneuroim.2004.11.014 |
| Abstrakt: |
SJL mice immunized with mannosylated (M-) PLP(139-151) in complete adjuvant do not develop EAE and little CNS mononuclear cell infiltration; other mannosylated peptides were ineffective in this experimental setting. Despite apparently normal T cell responses, M-PLP(139-151)-immunized mice show impaired delayed-type-sensitivity to PLP(139-151) but a normal response to other peptides. After re-immunization with PLP(139-151) in complete adjuvant, these mice are largely tolerant to EAE, show less T cell proliferation and decreased peptide-specific IgG2a. Our data suggest that M-PLP(139-151) induces peptide-specific tolerance to EAE via a mechanism of deletion or impaired migration of encephalitogenic T cells. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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