| Autor: |
Benedek K; Microbiology and Tumorbiology Centre, Karolinska Institute, Stockholm, Sweden., Chudoba I, Klein G, Wiener F, Mai S |
| Jazyk: |
angličtina |
| Zdroj: |
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology [Chromosome Res] 2004; Vol. 12 (8), pp. 777-85. |
| DOI: |
10.1007/s10577-005-5264-z |
| Abstrakt: |
Previous work has demonstrated that chromosome 11 is trisomic or shows a duplicated region encompassing the E1/E2 band of chromosome 11 in 90% of v-abl/myc-induced plasmacytomas (Wiener et al. 1995). In the present report, we have studied BALB/c PreB lymphocytes that were immortalized by v-abl and stably transfected with a conditional MycER vector (Mai et al. 1999). These cells, termed PreB ABL/MYC, showed changes in the E1/E2 bands of chromosome 11 that are similar to those reported previously for v-abl/myc-induced plasmacytomas. This was shown by the use of chromosome painting, SKY, FISH and mBAND. Our findings suggest that the Pre-B ABL/MYC cells may be used to analyse the genetic changes affecting chromosome 11 that are associated with v-abl/myc-dependent tumorigenesis in mouse B cells. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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