| Autor: |
Ehrlich LI; Department of Microbiology and Immunology and The Cancer Research Institute, University of California, San Francisco, CA 94143, USA., Ogasawara K, Hamerman JA, Takaki R, Zingoni A, Allison JP, Lanier LL |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2005 Feb 15; Vol. 174 (4), pp. 1922-31. |
| DOI: |
10.4049/jimmunol.174.4.1922 |
| Abstrakt: |
CD8+ T cells require a signal through a costimulatory receptor in addition to TCR engagement to become activated. The role of CD28 in costimulating T cell activation is well established. NKG2D, a receptor found on NK cells, CD8+ alphabeta-TCR+ T cells, and gammadelta-TCR+ T cells, has also been implicated in T cell costimulation. In this study we have evaluated the role of NKG2D in costimulating mouse and human naive and effector CD8+ T cells. Unexpectedly, in contrast to CD28, NKG2D engagement by ligand or mAb is not sufficient to costimulate naive or effector CD8+ T cell responses in conventional T cell populations. While NKG2D did not costimulate CD8+ T cells on its own, it was able to modify CD28-mediated costimulation of human CD8+ T cells under certain contitions. It is, therefore, likely that NKG2D acts as a costimulatory molecule only under restricted conditions or requires additional cofactors. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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